Predicting In Vivo Anti-Hepatofibrotic Drug Efficacy Based on In Vitro High-Content Analysis

Predicting In Vivo Anti-Hepatofibrotic Drug Efficacy Based on In Vitro High-Content Analysis

Background/Aims Many anti-fibrotic drugs with high in vitro efficacies fail to produce significant effects in vivo. The aim of this work is to use a statistical approach to design a numerical predictor that correlates better with in vivo outcomes. Methods High-content analysis (HCA) was per...

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Bibliographic Details
Main Authors: Zheng, Baixue, Tan, Looling, Mo, Xuejun, Yu, Weimiao, Wang, Yan, Tucker-Kellogg, Lisa, Welsch, Roy E., So, Peter T. C., Yu, Hanry
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Public Library of Science 2012
Online Access:http://hdl.handle.net/1721.1/69116
https://orcid.org/0000-0002-0339-3685
https://orcid.org/0000-0002-9038-1622
https://orcid.org/0000-0003-4698-6488

Internet

http://hdl.handle.net/1721.1/69116
https://orcid.org/0000-0002-0339-3685
https://orcid.org/0000-0002-9038-1622
https://orcid.org/0000-0003-4698-6488

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