Interleukin-1α induces ADAMTS-mediated aggrecanolysis in the bovine meniscus: evidence for a primary role of ADAMTS-4 in meniscus destruction

Interleukin-1α induces ADAMTS-mediated aggrecanolysis in the bovine meniscus: evidence for a primary role of ADAMTS-4 in meniscus destruction

Pro-inflammatory cytokines induce meniscal matrix degradation and inhibition of endogenous repair mechanisms, but the pathogenic mechanisms behind this are mostly unknown. Therefore, we investigated details of interleukin-1 (IL-1α)-induced aggrecan turnover in mature meniscal tissue explants. Fibro-...

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Bibliographic Details
Main Authors: Lemke, Angelika K., Sandy, John D., Voigt, Henning, Dreier, Rita, Lee, Jennifer H., Grodzinsky, Alan J., Mentlein, Rolf, Fay, Jakob, Schunke, Michael, Kurz, Bodo
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Springer-Verlag 2012
Online Access:http://hdl.handle.net/1721.1/69547
https://orcid.org/0000-0002-4942-3456

Internet

http://hdl.handle.net/1721.1/69547
https://orcid.org/0000-0002-4942-3456

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