Interleukin-1α induces ADAMTS-mediated aggrecanolysis in the bovine meniscus: evidence for a primary role of ADAMTS-4 in meniscus destruction
Pro-inflammatory cytokines induce meniscal matrix degradation and inhibition of endogenous repair mechanisms, but the pathogenic mechanisms behind this are mostly unknown. Therefore, we investigated details of interleukin-1 (IL-1α)-induced aggrecan turnover in mature meniscal tissue explants. Fibro-...
| Main Authors: | , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Springer-Verlag
2012
|
| Online Access: | http://hdl.handle.net/1721.1/69547 https://orcid.org/0000-0002-4942-3456 |