Synthesis of 7-aminocoumarin via Buchwald-Hartwig cross coupling for specific protein labeling in living cells

To enable minimally invasive studies of proteins in their native context, it is desirable to tag proteins with small, bright reporter groups. Recently, our lab described PRIME technology (for PRobe Incorporation Mediated by Enzymes) for such tagging[1-3]. An engineered variant of Escherichia coli li...

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Bibliographic Details
Main Authors: Jin, Xin, Uttamapinant, Chayasith, Ting, Alice Y.
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: Wiley-VCH Verlag 2012
Online Access:http://hdl.handle.net/1721.1/69559
https://orcid.org/0000-0002-8277-5226