A general screening strategy for peptide-based fluorogenic ligands

A systematic and general approach for identifying efficient probes for class I PDZ domains based on environment-sensitive chromophores is presented. A series of peptides derived from the C-terminal sequence of Stargazin was first used with PDZ domains of PSD-95 and Shank3 to identify the optimal pos...

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Bibliographic Details
Main Authors: Sainlos, Matthieu, Iskenderian, Wendy S., Imperiali, Barbara
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Chemical Society 2012
Online Access:http://hdl.handle.net/1721.1/69853
https://orcid.org/0000-0002-5749-7869