Insulin Dimer Dissociation and Unfolding Revealed by Amide I Two-Dimensional Infrared Spectroscopy

The monomer–dimer transition of insulin has been probed with two-dimensional infrared spectroscopy and related infrared spectroscopies to isolate spectral signatures of the conformational changes concomitant with dissociation. These experiments were atomistically interpreted using 2D IR spectra calc...

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Bibliographic Details
Main Authors: Ganim, Ziad, Jones, Kevin C., Tokmakoff, Andrei
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: Royal Society of Chemistry 2012
Online Access:http://hdl.handle.net/1721.1/69857