Nucleotide sequences and modifications that determine RIG-I/RNA binding and signaling activities
Cytoplasmic viral RNAs with 5′ triphosphates (5′ppp) are detected by the RNA helicase RIG-I, initiating downstream signaling and alpha/beta interferon (IFN-α/β) expression that establish an antiviral state. We demonstrate here that the hepatitis C virus (HCV) 3′ untranslated region (UTR) RNA has gre...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
American Society for Microbiology
2012
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| Online Access: | http://hdl.handle.net/1721.1/69882 https://orcid.org/0000-0002-9387-8212 |