BIC-seq: a fast algorithm for detection of copy number alterations based on high-throughput sequencing data

DNA copy number alterations (CNA), which are amplifications and deletions of certain regions in the genome, play an important role in the pathogenesis of cancer and have been shown to be associated with other diseases such as autism, schizophrenia and obesity.

Bibliographic Details
Main Authors: Xi, Ruibin, Luquette, Joe, Hadjipanayis, Angela, Kim, Tae-Min, Park, Peter J.
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: BioMed Central Ltd. 2012
Online Access:http://hdl.handle.net/1721.1/69934