Rational Design of New Binding Specificity by Simultaneous Mutagenesis of Calmodulin and a Target Peptide

Rational Design of New Binding Specificity by Simultaneous Mutagenesis of Calmodulin and a Target Peptide

Calcium-saturated calmodulin (CaM) binds and influences the activity of a varied collection of target proteins in most cells. This promiscuity underlies the role of CaM as a shared participant in calcium-dependent signal transduction pathways but imposes a handicap on popular CaM-based calcium biose...

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Bibliographic Details
Main Authors: Green, David F., Dennis, Andrew T., Fam, Peter S., Tidor, Bruce, Jasanoff, Alan Pradip
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Format: Article
Language:en_US
Published: American Chemical Society (ACS) 2012
Online Access:http://hdl.handle.net/1721.1/69997
https://orcid.org/0000-0002-3320-3969
https://orcid.org/0000-0002-2834-6359

Internet

http://hdl.handle.net/1721.1/69997
https://orcid.org/0000-0002-3320-3969
https://orcid.org/0000-0002-2834-6359

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