Motor Mechanism for Protein Threading through Hsp104

The protein-remodeling machine Hsp104 dissolves amorphous aggregates as well as ordered amyloid assemblies such as yeast prions. Force generation originates from a tandem AAA+ (ATPases associated with various cellular activities) cassette, but the mechanism and allostery of this action remain to be...

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Bibliographic Details
Main Authors: Wendler, Petra, Shorter, James, Snead, David, Plisson, Celia, Clare, Daniel K., Saibil, Helen R., Lindquist, Susan
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2012
Online Access:http://hdl.handle.net/1721.1/70958
https://orcid.org/0000-0003-1307-882X