Enhanced multiplex genome engineering through co-operative oligonucleotide co-selection
Genome-scale engineering of living organisms requires precise and economical methods to efficiently modify many loci within chromosomes. One such example is the directed integration of chemically synthesized single-stranded deoxyribonucleic acid (oligonucleotides) into the chromosome of Escherichia...
Main Authors: | Carr, Peter A., Sr., Wang, Harris H., Sterling, Bram Henry, Isaacs, Farren J., Lajoie, Marc J., Xu, George Jing, Church, George M., Jacobson, Joseph |
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Other Authors: | Harvard University--MIT Division of Health Sciences and Technology |
Format: | Article |
Language: | en_US |
Published: |
Oxford University Press (OUP)
2012
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Online Access: | http://hdl.handle.net/1721.1/71773 https://orcid.org/0000-0002-1332-3197 https://orcid.org/0000-0003-3222-0772 |
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