Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase

Essential for DNA biosynthesis and repair, ribonucleotide reductases (RNRs) convert ribonucleotides to deoxyribonucleotides via radical-based chemistry. Although long known that allosteric regulation of RNR activity is vital for cell health, the molecular basis of this regulation has been enigmatic,...

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Bibliographic Details
Main Authors: Ando, Nozomi, Brignole, Edward J., Zimanyi, Christina M., Funk, Michael Andrew, Yokoyama, Kenichi, Asturias, Francisco J., Stubbe, JoAnne, Drennan, Catherine L
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: National Academy of Sciences of the United States of America 2012
Online Access:http://hdl.handle.net/1721.1/71843
https://orcid.org/0000-0001-5486-2755
https://orcid.org/0000-0001-8076-4489