Structural interconversions modulate activity of Escherichia coli ribonucleotide reductase
Essential for DNA biosynthesis and repair, ribonucleotide reductases (RNRs) convert ribonucleotides to deoxyribonucleotides via radical-based chemistry. Although long known that allosteric regulation of RNR activity is vital for cell health, the molecular basis of this regulation has been enigmatic,...
Main Authors: | , , , , , , , |
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Other Authors: | |
Format: | Article |
Language: | en_US |
Published: |
National Academy of Sciences of the United States of America
2012
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Online Access: | http://hdl.handle.net/1721.1/71843 https://orcid.org/0000-0001-5486-2755 https://orcid.org/0000-0001-8076-4489 |