2D protrusion but not motility predicts growth factor–induced cancer cell migration in 3D collagen

Growth factor–induced migration is a critical step in the dissemination and metastasis of solid tumors. Although differences in properties characterizing cell migration on two-dimensional (2D) substrata versus within three-dimensional (3D) matrices have been noted for particular growth factor stimul...

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Bibliographic Details
Main Authors: Meyer, Aaron Samuel, Hughes-Alford, Shannon Kay, Kay, Jennifer Elizabeth, Castillo, Amalchi, Wells, Alan, Gertler, Frank, Lauffenburger, Douglas A
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Rockefeller University Press, The 2012
Online Access:http://hdl.handle.net/1721.1/71869
https://orcid.org/0000-0001-5891-0689
https://orcid.org/0000-0003-3214-4554