Room Temperature Aryl Trifluoromethylation via Copper- Mediated Oxidative Cross-Coupling
A method for the room temperature copper-mediated trifluoromethylation of aryl and heteroaryl boronic acids has been developed. This protocol is amenable to normal benchtop setup and reactions typically require only 1−4 h. Proceeding under mild conditions, the method tolerates a range of functional...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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American Chemical Society (ACS)
2012
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| Online Access: | http://hdl.handle.net/1721.1/71959 https://orcid.org/0000-0003-3875-4775 |
| _version_ | 1811084853483929600 |
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| author | Buchwald, Stephen Leffler Senecal, Todd D. Parsons, Andrew |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Buchwald, Stephen Leffler Senecal, Todd D. Parsons, Andrew |
| author_sort | Buchwald, Stephen Leffler |
| collection | MIT |
| description | A method for the room temperature copper-mediated trifluoromethylation of aryl and heteroaryl boronic acids has been developed. This protocol is amenable to normal benchtop setup and reactions typically require only 1−4 h. Proceeding under mild conditions, the method tolerates a range of functional groups, allowing access to a variety of trifluoromethylarenes. |
| first_indexed | 2024-09-23T12:58:37Z |
| format | Article |
| id | mit-1721.1/71959 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T12:58:37Z |
| publishDate | 2012 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/719592022-10-01T12:15:31Z Room Temperature Aryl Trifluoromethylation via Copper- Mediated Oxidative Cross-Coupling Buchwald, Stephen Leffler Senecal, Todd D. Parsons, Andrew Massachusetts Institute of Technology. Department of Chemistry Buchwald, Stephen L. Buchwald, Stephen Leffler Senecal, Todd D. Parsons, Andrew A method for the room temperature copper-mediated trifluoromethylation of aryl and heteroaryl boronic acids has been developed. This protocol is amenable to normal benchtop setup and reactions typically require only 1−4 h. Proceeding under mild conditions, the method tolerates a range of functional groups, allowing access to a variety of trifluoromethylarenes. National Institutes of Health (U.S.) (grant no. GM-46059) National Institutes of Health (U.S.) (grant no. 1F32GM093532) National Science Foundation (U.S.) (grant no. CHE-9808061) National Science Foundation (U.S.) (grant no. DBI-9729592) 2012-08-02T18:42:27Z 2012-08-02T18:42:27Z 2011-01 2010-11 Article http://purl.org/eprint/type/JournalArticle 0022-3263 1520-6904 http://hdl.handle.net/1721.1/71959 Buchwald, Stephen Leffler, Andrew T. Parsons, and Todd D. Senecal. "Room Temperature Aryl Trifluoromethylation via Copper-Mediated Oxidative Cross-Coupling." The Journal of Organic Chemistry 76.4 (2011): 1174-1176. https://orcid.org/0000-0003-3875-4775 en_US http://dx.doi.org/10.1021/jo1023377 Journal of Organic Chemistry Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society (ACS) PMC |
| spellingShingle | Buchwald, Stephen Leffler Senecal, Todd D. Parsons, Andrew Room Temperature Aryl Trifluoromethylation via Copper- Mediated Oxidative Cross-Coupling |
| title | Room Temperature Aryl Trifluoromethylation via Copper- Mediated Oxidative Cross-Coupling |
| title_full | Room Temperature Aryl Trifluoromethylation via Copper- Mediated Oxidative Cross-Coupling |
| title_fullStr | Room Temperature Aryl Trifluoromethylation via Copper- Mediated Oxidative Cross-Coupling |
| title_full_unstemmed | Room Temperature Aryl Trifluoromethylation via Copper- Mediated Oxidative Cross-Coupling |
| title_short | Room Temperature Aryl Trifluoromethylation via Copper- Mediated Oxidative Cross-Coupling |
| title_sort | room temperature aryl trifluoromethylation via copper mediated oxidative cross coupling |
| url | http://hdl.handle.net/1721.1/71959 https://orcid.org/0000-0003-3875-4775 |
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