Exocyclic Carbons Adjacent to the N[superscript 6] of Adenine are Targets for Oxidation by the Escherichia coli Adaptive Response Protein AlkB

Exocyclic Carbons Adjacent to the N[superscript 6] of Adenine are Targets for Oxidation by the Escherichia coli Adaptive Response Protein AlkB

The DNA and RNA repair protein AlkB removes alkyl groups from nucleic acids by a unique iron- and α-ketoglutarate-dependent oxidation strategy. When alkylated adenines are used as AlkB targets, earlier work suggests that the initial target of oxidation can be the alkyl carbon adjacent to N1. Such ma...

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Bibliographic Details
Main Authors: Li, Deyu, Delaney, James C., Page, Charlotte M., Yang, Xuedong, Chen, Alvin S., Wong, Cintyu, Essigmann, John M., Drennan, Catherine L
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences
Format: Article
Language:en_US
Published: American Chemical Society (ACS) 2012
Online Access:http://hdl.handle.net/1721.1/71978
https://orcid.org/0000-0001-5486-2755
https://orcid.org/0000-0001-6159-0778
https://orcid.org/0000-0002-2196-5691

Internet

http://hdl.handle.net/1721.1/71978
https://orcid.org/0000-0001-5486-2755
https://orcid.org/0000-0001-6159-0778
https://orcid.org/0000-0002-2196-5691

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