Stromal cell-derived factor-1 overexpression induces gastric dysplasia through expansion of stromal myofibroblasts and epithelial progenitors

Stromal cell-derived factor-1 overexpression induces gastric dysplasia through expansion of stromal myofibroblasts and epithelial progenitors

Objective: Stromal cell-derived factor-1 (SDF-1/CXCL12), the main ligand for CXCR4, is overexpressed in human cancer. This study addressed the precise contribution of SDF-1 to gastric carcinogenesis. Design: SDF-1 transgenic mice were created and a Helicobacter-induced gastric cancer model was us...

Full description

Bibliographic Details
Main Authors: Shibata, Wataru, Ariyama, Hiroshi, Westphalen, Christoph Benedikt, Worthley, Daniel L., Muthupalani, Sureshkumar, Asfaha, Samuel, Dubeykovskaya, Zinaida, Quante, Michael, Fox, James G., Wang, Timothy C.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: BMJ Publishing Group 2012
Online Access:http://hdl.handle.net/1721.1/72115
https://orcid.org/0000-0001-9307-6116

Internet

http://hdl.handle.net/1721.1/72115
https://orcid.org/0000-0001-9307-6116

Similar Items