A hot oxidant, 3-NO[subscript 2]Y[subscript 122] radical, unmasks conformational gating in reductase

Escherichia coli ribonucleotide reductase is an α2β2 complex that catalyzes the conversion of nucleotides to deoxynucleotides and requires a diferric-tyrosyl radical (Y[superscript •]) cofactor to initiate catalysis. The initiation process requires long-range proton-coupled electron transfer (PCET)...

Full description

Bibliographic Details
Main Authors: Yokoyama, Kenichi, Uhlin, Ulla, Stubbe, JoAnne
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Chemical Society (ACS) 2012
Online Access:http://hdl.handle.net/1721.1/72149
https://orcid.org/0000-0001-8076-4489