A hot oxidant, 3-NO[subscript 2]Y[subscript 122] radical, unmasks conformational gating in reductase
Escherichia coli ribonucleotide reductase is an α2β2 complex that catalyzes the conversion of nucleotides to deoxynucleotides and requires a diferric-tyrosyl radical (Y[superscript •]) cofactor to initiate catalysis. The initiation process requires long-range proton-coupled electron transfer (PCET)...
| Principais autores: | , , |
|---|---|
| Outros Autores: | |
| Formato: | Artigo |
| Idioma: | en_US |
| Publicado em: |
American Chemical Society (ACS)
2012
|
| Acesso em linha: | http://hdl.handle.net/1721.1/72149 https://orcid.org/0000-0001-8076-4489 |