A hot oxidant, 3-NO[subscript 2]Y[subscript 122] radical, unmasks conformational gating in reductase

A hot oxidant, 3-NO[subscript 2]Y[subscript 122] radical, unmasks conformational gating in reductase

Escherichia coli ribonucleotide reductase is an α2β2 complex that catalyzes the conversion of nucleotides to deoxynucleotides and requires a diferric-tyrosyl radical (Y[superscript •]) cofactor to initiate catalysis. The initiation process requires long-range proton-coupled electron transfer (PCET)...

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Bibliographic Details
Main Authors:	Yokoyama, Kenichi, Uhlin, Ulla, Stubbe, JoAnne
Other Authors:	Massachusetts Institute of Technology. Department of Biology
Format:	Article
Language:	en_US
Published:	American Chemical Society (ACS) 2012
Online Access:	http://hdl.handle.net/1721.1/72149 https://orcid.org/0000-0001-8076-4489

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