A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination

A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination

RNA crystallization and phasing represent major bottlenecks in RNA structure determination. Seeking to exploit antibody fragments as RNA crystallization chaperones, we have used an arginine-enriched synthetic Fab library displayed on phage to obtain Fabs against the class I ligase ribozyme. We solve...

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Bibliographic Details
Main Authors: Koldobskaya, Yelena, Duguid, Erica M., Shechner, David M., Suslov, Nikolai B., Ye, Jingdong, Sidhu, Sachdev S., Bartel, David, Koide, Shohei, Kossiakoff, Anthony A., Piccirilli, Joseph A.
Other Authors: move to dc.description.sponsorship
Format: Article
Language:en_US
Published: Nature Publishing Group 2012
Online Access:http://hdl.handle.net/1721.1/72384
https://orcid.org/0000-0002-3872-2856

Internet

http://hdl.handle.net/1721.1/72384
https://orcid.org/0000-0002-3872-2856

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