Mechanical compression drives cancer cells toward invasive phenotype

Mechanical compression drives cancer cells toward invasive phenotype

Uncontrolled growth in a confined space generates mechanical compressive stress within tumors, but little is known about how such stress affects tumor cell behavior. Here we show that compressive stress stimulates migration of mammary carcinoma cells. The enhanced migration is accomplished by a subs...

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Bibliographic Details
Main Authors: Tse, Janet M., Cheng, Gang, Tyrrell, James A., Wilcox-Adelman, Sarah A., Boucher, Yves, Jain, Rakesh K., Munn, Lance L.
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:en_US
Published: National Academy of Sciences 2012
Online Access:http://hdl.handle.net/1721.1/72496

Internet

http://hdl.handle.net/1721.1/72496

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