SIRT1 Protects against α-Synuclein Aggregation by Activating Molecular Chaperones

SIRT1 Protects against α-Synuclein Aggregation by Activating Molecular Chaperones

α-Synuclein is a key molecule in the pathogenesis of synucleinopathy including dementia with Lewy bodies, Parkinson's disease, and multiple system atrophy. Sirtuins are NAD[superscript +]-dependent protein deacetylases that are highly conserved and counter aging in lower organisms. We show that...

Full description

Bibliographic Details
Main Authors: Donmez Yalcin, Gizem, Arun, Anirudh, Chung, Chee Yeun, McLean, Pamela J., Lindquist, Susan, Guarente, Leonard Pershing
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Society for Neuroscience 2012
Online Access:http://hdl.handle.net/1721.1/72526
https://orcid.org/0000-0003-1307-882X
https://orcid.org/0000-0003-4064-2510

Internet

http://hdl.handle.net/1721.1/72526
https://orcid.org/0000-0003-1307-882X
https://orcid.org/0000-0003-4064-2510

Similar Items