Defects in purine nucleotide metabolism lead to substantial incorporation of xanthine and hypoxanthine into DNA and RNA

Defects in purine nucleotide metabolism lead to substantial incorporation of xanthine and hypoxanthine into DNA and RNA

Deamination of nucleobases in DNA and RNA results in the formation of xanthine (X), hypoxanthine (I), oxanine, and uracil, all of which are miscoding and mutagenic in DNA and can interfere with RNA editing and function. Among many forms of nucleic acid damage, deamination arises from several unrelat...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Pang, Bo, McFaline, Jose Luis, Burgis, Nicholas E., Taghizadeh, Koli, Sullivan, Matthew R., Elmquist, C. Eric, Cunningham, Richard P., Dedon, Peter C., Dong, Min, 1968-
Άλλοι συγγραφείς: Massachusetts Institute of Technology. Center for Environmental Health Sciences
Μορφή: Άρθρο
Γλώσσα:en_US
Έκδοση: National Academy of Sciences 2012
Διαθέσιμο Online:http://hdl.handle.net/1721.1/72533
https://orcid.org/0000-0003-0011-3067
https://orcid.org/0000-0002-4607-5337

Διαδίκτυο

http://hdl.handle.net/1721.1/72533
https://orcid.org/0000-0003-0011-3067
https://orcid.org/0000-0002-4607-5337

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