Direct visualization of DNA affinity landscapes using a highthroughput sequencing instrument

Direct visualization of DNA affinity landscapes using a highthroughput sequencing instrument

Several methods for characterizing DNA-protein interactions are available, but none have demonstrated both high throughput and quantitative measurement of affinity. Here we describe 'high-throughput sequencing'-'fluorescent ligand interaction profiling' (HiTS-FLIP), a technique f...

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Bibliographic Details
Main Authors: Nutiu, Razvan, Friedman, Robin Carl, Luo, Shujun, Khrebtukova, Irina, Silva, David, Li, Robin, Zhang, Lu, Schroth, Gary P., Burge, Christopher B.
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program
Format: Article
Language:en_US
Published: Nature Publishing Group 2012
Online Access:http://hdl.handle.net/1721.1/72567

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http://hdl.handle.net/1721.1/72567

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