Direct visualization of DNA affinity landscapes using a highthroughput sequencing instrument
Several methods for characterizing DNA-protein interactions are available, but none have demonstrated both high throughput and quantitative measurement of affinity. Here we describe 'high-throughput sequencing'-'fluorescent ligand interaction profiling' (HiTS-FLIP), a technique f...
Main Authors: | , , , , , , , , |
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Other Authors: | |
Format: | Article |
Language: | en_US |
Published: |
Nature Publishing Group
2012
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Online Access: | http://hdl.handle.net/1721.1/72567 |