RNA Folding with Soft Constraints: Reconciliation of Probing Data and Thermodynamic Secondary Structure Prediction

RNA Folding with Soft Constraints: Reconciliation of Probing Data and Thermodynamic Secondary Structure Prediction

Thermodynamic folding algorithms and structure probing experiments are commonly used to determine the secondary structure of RNAs. Here we propose a formal framework to reconcile information from both prediction algorithms and probing experiments. The thermodynamic energy parameters are adjusted usi...

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Bibliographic Details
Main Authors: Mag Washietl, Stefan, Hofacker, Ivo L., Stadler, Peter F., Kellis, Manolis
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Format: Article
Language:en_US
Published: Oxford University Press 2012
Online Access:http://hdl.handle.net/1721.1/73037

Internet

http://hdl.handle.net/1721.1/73037

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