Overexpression of CREB in the Nucleus Accumbens Shell Increases Cocaine Reinforcement in Self-Administering Rats
Chronic exposure to addictive drugs enhances cAMP response element binding protein (CREB)-regulated gene expression in nucleus accumbens (NAc), and these effects are thought to reduce the positive hedonic effects of passive cocaine administration. Here, we used viral-mediated gene transfer to produc...
Main Authors: | Larson, Erin B., Graham, Danielle L., Arzaga, Rose R., Buzin, Nicole, Webb, Joseph, Green, Thomas A., Bass, Caroline E., Neve, Rachael L., Terwilliger, Ernest F., Nestler, Eric J., Self, David W. |
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Other Authors: | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
Format: | Article |
Language: | en_US |
Published: |
Society for Neuroscience
2012
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Online Access: | http://hdl.handle.net/1721.1/73068 https://orcid.org/0000-0002-3854-5968 |
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