Explaining the Structural Plasticity of α-Synuclein

Given that α-synuclein has been implicated in the pathogenesis of several neurodegenerative disorders, deciphering the structure of this protein is of particular importance. While monomeric α-synuclein is disordered in solution, it can form aggregates rich in cross-β structure, relatively long helic...

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Bibliographic Details
Main Authors: Ullman, Orly, Fisher, Charles K., Stultz, Collin M.
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: American Chemical Society (ACS) 2012
Online Access:http://hdl.handle.net/1721.1/73165
https://orcid.org/0000-0002-3415-242X