Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression

Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression

Alterations in DNA methylation have been associated with genome-wide hypomethylation and regional de novo methylation in numerous cancers. De novo methylation is mediated by the de novo methyltransferases Dnmt3a and 3b, but only Dnmt3b has been implicated in promoting cancer by silencing of tumor-su...

Full description

Bibliographic Details
Main Authors: Gao, Qing, Steine, Eveline J., Barrasa, M. Inmaculada, Hockemeyer, Dirk, Pawlak, Mathias, Fu, Dongdong, Reddy, Seshamma, Bell, George W., Jaenisch, Rudolf
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: National Academy of Sciences 2012
Online Access:http://hdl.handle.net/1721.1/73173

Internet

http://hdl.handle.net/1721.1/73173

Similar Items