Determinants of BH3 Binding Specificity for Mcl-1 versus BcI-x[subscript L]
Interactions among Bcl-2 family proteins are important for regulating apoptosis. Prosurvival members of the family interact with proapoptotic BH3 (Bcl-2-homology-3)-only members, inhibiting execution of cell death through the mitochondrial pathway. Structurally, this interaction is mediated by bindi...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Elsevier
2012
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| Online Access: | http://hdl.handle.net/1721.1/73465 https://orcid.org/0000-0003-4074-8980 |