Additivity in the Analysis and Design of HIV Protease Inhibitors

Additivity in the Analysis and Design of HIV Protease Inhibitors

We explore the applicability of an additive treatment of substituent effects to the analysis and design of HIV protease inhibitors. Affinity data for a set of inhibitors with a common chemical framework were analyzed to provide estimates of the free energy contribution of each chemical substituent....

Full description

Bibliographic Details
Main Authors: Jorissen, Robert N., Kumar Reddy, G. S. Kiran, Ali, Akbar, Altman, Michael D., Chellappan, Sripriya, Anjum, Saima G., Tidor, Bruce, Schiffer, Celia A., Rana, Tariq M., Gilson, Michael K.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: American Chemical Society (ACS) 2012
Online Access:http://hdl.handle.net/1721.1/73544
https://orcid.org/0000-0002-3320-3969

Internet

http://hdl.handle.net/1721.1/73544
https://orcid.org/0000-0002-3320-3969

Similar Items