Searching for DNA Lesions: Structural Evidence for Lower- and Higher-Affinity DNA Binding Conformations of Human Alkyladenine DNA Glycosylase

Searching for DNA Lesions: Structural Evidence for Lower- and Higher-Affinity DNA Binding Conformations of Human Alkyladenine DNA Glycosylase

To efficiently repair DNA, human alkyladenine DNA glycosylase (AAG) must search the million-fold excess of unmodified DNA bases to find a handful of DNA lesions. Such a search can be facilitated by the ability of glycosylases, like AAG, to interact with DNA using two affinities: a lower-affinity int...

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Bibliographic Details
Main Authors: Setser, Jeremy W., Lingaraju, Gondichatnahalli M., Davis, C. Ainsley, Samson, Leona D., Drennan, Catherine L
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences
Format: Article
Language:en_US
Published: American Chemical Society 2012
Online Access:http://hdl.handle.net/1721.1/73589
https://orcid.org/0000-0001-5486-2755

Internet

http://hdl.handle.net/1721.1/73589
https://orcid.org/0000-0001-5486-2755

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