Scaffold number in yeast signaling system sets tradeoff between system output and dynamic range

Although the proteins comprising many signaling systems are known, less is known about their numbers per cell. Existing measurements often vary by more than 10-fold. Here, we devised improved quantification methods to measure protein abundances in the Saccharomyces cerevisiae pheromone response path...

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Bibliographic Details
Main Authors: Thomson, Ty M., Benjamin, Kirsten R., Bush, Alan, Love, Tonya, Pincus, David, Resnekov, Orna, Yu, Richard C., Gordon, Andrew, Colman-Lerner, Alejandro, Endy, Drew, Brent, Roger
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: National Academy of Sciences 2012
Online Access:http://hdl.handle.net/1721.1/73893