The Radical Use of Rossmann and TIM Barrel Architectures for Controlling Coenzyme B[subscript 12] Chemistry

The ability of enzymes to harness free-radical chemistry allows for some of the most amazing transformations in nature, including reduction of ribonucleotides and carbon skeleton rearrangements. Enzyme cofactors involved in this chemistry can be large and complex, such as adenosylcobalamin (coenzyme...

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Bibliographic Details
Main Authors: Dowling, Daniel P., Croft, Anna K., Drennan, Catherine L
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Annual Reviews 2012
Online Access:http://hdl.handle.net/1721.1/74068
https://orcid.org/0000-0001-5486-2755