Rapid dissection and model-based optimization of inducible enhancers in human cells using a massively parallel reporter assay

Rapid dissection and model-based optimization of inducible enhancers in human cells using a massively parallel reporter assay

Learning to read and write the transcriptional regulatory code is of central importance to progress in genetic analysis and engineering. Here we describe a massively parallel reporter assay (MPRA) that facilitates the systematic dissection of transcriptional regulatory elements. In MPRA, microarray-...

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Bibliographic Details
Main Authors: Melnikov, Alexandre, Murugan, Anand, Zhang, Xiaolan, Tesileanu, Tiberiu, Wang, Li, Rogov, Peter, Feizi-Khankandi, Soheil, Gnirke, Andreas, Callan Jr, Curtis G., Kinney, Justin B., Kellis, Manolis, Lander, Eric S., Mikkelsen, Tarjei Sigurd, 1978-
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Format: Article
Language:en_US
Published: Nature Publishing Group 2012
Online Access:http://hdl.handle.net/1721.1/74097
https://orcid.org/0000-0002-0964-0616

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