XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells

XBP-1, a transcription factor that drives the unfolded protein response (UPR), is activated in B cells when they differentiate to plasma cells. Here, we show that in the B cells, whose capacity to secrete IgM has been eliminated, XBP-1 is induced normally on induction of differentiation, suggesting...

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Bibliographic Details
Main Authors: Hu, Chih-Chi Andrew, Dougan, Stephanie K., McGehee, Annette M., Ploegh, Hidde, Love, John C
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Nature Publishing Group 2012
Online Access:http://hdl.handle.net/1721.1/74263
https://orcid.org/0000-0003-0921-3144
https://orcid.org/0000-0002-1090-6071