A unique regulatory phase of DNA methylation in the early mammalian embryo

DNA methylation is highly dynamic during mammalian embryogenesis. It is broadly accepted that the paternal genome is actively depleted of 5-methylcytosine at fertilization, followed by passive loss that reaches a minimum at the blastocyst stage. However, this model is based on limited data, and so f...

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Detalhes bibliográficos
Principais autores: Chan, Michelle Mei Wah, Regev, Aviv, Smith, Zachary D., Gu, Hongcang, Gnirke, Andreas, Meissner, Alexander, Mikkelsen, Tarjei Sigurd, 1978-
Outros Autores: Massachusetts Institute of Technology. Computational and Systems Biology Program
Formato: Artigo
Idioma:en_US
Publicado em: Nature Publishing Group 2012
Acesso em linha:http://hdl.handle.net/1721.1/74536
https://orcid.org/0000-0001-8567-2049