Rapamycin inhibits mTORC1, but not completely
Rapamycin is widely used as a complete inhibitor of the mTORC1 nutrient-sensitive signaling complex. Using a novel ATP-competitive inhibitor named Torin1, we have found that many mTORC1 functions that regulate cap-dependent translation and autophagy are resistant to inhibition by rapamycin.
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Landes Bioscience
2012
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| Online Access: | http://hdl.handle.net/1721.1/74547 https://orcid.org/0000-0002-1446-7256 |