Fast, Cell-Compatible Click Chemistry with Copper-Chelating Azides for Biomolecular Labeling

Fast, Cell-Compatible Click Chemistry with Copper-Chelating Azides for Biomolecular Labeling

Bring your own copper: Copper-chelating azides undergo much faster click reactions (CuAAC) than nonchelating azides under a variety of biocompatible conditions. This kinetic enhancement allows site-specific protein labeling to be performed on the surface of living cells with only 10–40 μM Cu[supersc...

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Bibliographic Details
Main Authors: Uttamapinant, Chayasith, Tangpeerachaikul, Anupong, Grecian, Scott, Clarke, Scott M., Singh, Upinder, Slade, Peter, Gee, Kyle R., Ting, Alice Y.
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: Wiley Blackwell 2012
Online Access:http://hdl.handle.net/1721.1/74563
https://orcid.org/0000-0002-8277-5226

Internet

http://hdl.handle.net/1721.1/74563
https://orcid.org/0000-0002-8277-5226

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