Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs
MicroRNAs (miRNAs) are 19–22-nucleotide noncoding RNAs that post-transcriptionally regulate mRNA targets. We have identified endogenous miRNA binding sites in mouse embryonic stem cells (mESCs), by performing photo-cross-linking immunoprecipitation using antibodies to Argonaute (Ago2) followed by de...
Main Authors: | Leung, Anthony, Young, Amanda G., Bhutkar, Arjun (AJ), Zheng, Grace X., Bosson, Andrew David, Nielsen, Cydney B., Sharp, Phillip A. |
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Other Authors: | Massachusetts Institute of Technology. Computational and Systems Biology Program |
Format: | Article |
Language: | en_US |
Published: |
Nature Publishing Group
2012
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Online Access: | http://hdl.handle.net/1721.1/74622 https://orcid.org/0000-0003-1465-1691 |
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