MicroRNAs can generate thresholds in target gene expression

MicroRNAs (miRNAs) are short, highly conserved noncoding RNA molecules that repress gene expression in a sequence-dependent manner. We performed single-cell measurements using quantitative fluorescence microscopy and flow cytometry to monitor a target gene's protein expression in the presence a...

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Bibliographic Details
Main Authors: Mukherji, Shankar, Ebert, Margaret S., Sharp, Phillip A., van Oudenaarden, Alexander, Tsang, John S., Zheng, Xinying Grace
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: Nature Publishing Group 2012
Online Access:http://hdl.handle.net/1721.1/74623
https://orcid.org/0000-0003-1465-1691