Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase

Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase

Little is known about quality control of proteins that aberrantly or persistently engage the endoplasmic reticulum (ER)-localized translocon en route to membrane localization or the secretory pathway. Hrd1 and Doa10, the primary ubiquitin ligases that function in ER-associated degradation (ERAD) in...

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Bibliographic Details
Main Authors: Greenblatt, Wesley H., Rubenstein, Eric M., Kreft, Stefan G., Swanson, Robert, Hochstrasser, Mark
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: Rockefeller University Press, The 2012
Online Access:http://hdl.handle.net/1721.1/74669

Internet

http://hdl.handle.net/1721.1/74669

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