Over Expression of the CMP-sialic Acid Transporter in Chinese Hamster Ovary Cells Leads to Increased Sialylation

Over Expression of the CMP-sialic Acid Transporter in Chinese Hamster Ovary Cells Leads to Increased Sialylation

Most glyco-engineering approaches used to improve quality of recombinant glycoproteins involve the manipulation of glycosyltransferase and/or glycosidase expression. We investigated whether the over expression of nucleotide sugar transporters, particularly the CMP-sialic acid transporter (CMP-SAT),...

Full description

Bibliographic Details
Main Authors: Wong, Niki S.C., Yap, Miranda G.S., Wang, Daniel I.C.
Format: Article
Language:English
Published: 2004
Subjects:
Chinese Hamster Ovary (CHO) cells
Over expression
Protein Quality
Sialylation
Transport
Online Access:http://hdl.handle.net/1721.1/7487

Internet

http://hdl.handle.net/1721.1/7487

Similar Items