Dysregulation of dopamine receptor D2 as a sensitive measure for Huntington disease pathology in model mice

The ability to quantitatively evaluate the impact of a potential therapeutic intervention for Huntington disease (HD) in animal models for the disease is a critical step in the pathway to development of an effective therapy for this devastating neurodegenerative disorder. We report here an approach...

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Bibliographic Details
Main Authors: Crook, Zachary Ryan, Housman, David E
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:en_US
Published: National Academy of Sciences 2012
Online Access:http://hdl.handle.net/1721.1/75395
https://orcid.org/0000-0002-1142-9748
https://orcid.org/0000-0001-5016-0756