Engineered Bivalent Ligands to Bias ErbB Receptor-mediated Signaling and Phenotypes

Engineered Bivalent Ligands to Bias ErbB Receptor-mediated Signaling and Phenotypes

The ErbB receptor family is dysregulated in many cancers, and its therapeutic manipulation by targeted antibodies and kinase inhibitors has resulted in effective chemotherapies. However, many malignancies remain refractory to current interventions. We describe a new approach that directs ErbB recept...

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Bibliographic Details
Main Authors: Jay, Steven M., Kurtagic, Elma, Alvarez, Luis M., De Picciotto, Seymour, Hawkins, Jessica F., Prince, Robin N., Guerrero, Yadir, Treasure, Carolyn L., Lee, Richard T., Griffith, Linda G., Sanchez, Edgar
Other Authors: Massachusetts Institute of Technology. Center for Gynepathology Research
Format: Article
Language:en_US
Published: American Society for Biochemistry and Molecular Biology (ASBMB) 2012
Online Access:http://hdl.handle.net/1721.1/75785

Internet

http://hdl.handle.net/1721.1/75785

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