mTORC1 in the Paneth cell niche couples intestinal stem cell function to calorie intake

mTORC1 in the Paneth cell niche couples intestinal stem cell function to calorie intake

How adult tissue stem and niche cells respond to the nutritional state of an organism is not well understood. Here we find that Paneth cells, a key constituent of the mammalian intestinal stem-cell (ISC) niche, augment stem-cell function in response to calorie restriction. Calorie restriction acts b...

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Bibliographic Details
Main Authors: Katajisto, Pekka, Lamming, Dudley W., Gultekin, Yetis, Bauer-Rowe, Khristian E., Sengupta, Shomit, Birsoy, Kivanc, Dursun, Abdulmetin, Yilmaz, V. Onur, Selig, Martin, Nielson, G. Petur, Mino-Kenudson, Mari, Zuckerberg, Lawrence, Bahn, Atul K., Deshpande, Vikram, Yilmaz, Omer, Sabatini, David
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Nature Publishing Group 2012
Online Access:http://hdl.handle.net/1721.1/75789
https://orcid.org/0000-0002-0079-4467
https://orcid.org/0000-0002-7577-4612
https://orcid.org/0000-0002-1446-7256

Internet

http://hdl.handle.net/1721.1/75789
https://orcid.org/0000-0002-0079-4467
https://orcid.org/0000-0002-7577-4612
https://orcid.org/0000-0002-1446-7256

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