ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein

ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein

Prodomains of A disintegrin and metalloproteinase (ADAM) metallopeptidases can act as highly specific intra- and intermolecular inhibitors of ADAM catalytic activity. The mouse ADAM9 prodomain (proA9; amino acids 24–204), expressed and characterized from Escherichia coli, is a competitive inhibitor...

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Bibliographic Details
Main Authors: Moss, Marcia L., Powell, Gary, Miller, Miles Aaron, Edwards, Lori, Qi, Bin, Qing-Xiang Amy, Sang, De Strooper, Bart, Tesseur, Ina, Lichtenthaler, Stefan F., Taverna, Mara, Zhong, Julia Li, Dingwall, Colin, Ferdous, Taheera, Schlomann, Uwe, Zhou, Pei, Griffith, Linda G., Lauffenburger, Douglas A., Petrovich, Robert, Bartsch, Jorg W.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: American Society for Biochemistry and Molecular Biology 2013
Online Access:http://hdl.handle.net/1721.1/76196
https://orcid.org/0000-0002-1801-5548

Internet

http://hdl.handle.net/1721.1/76196
https://orcid.org/0000-0002-1801-5548

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