Conjugating drug candidates to polymeric chains does not necessarily enhance anti-influenza activity

Conjugating drug candidates to polymeric chains does not necessarily enhance anti-influenza activity

Using the plaque reduction assay, relatively simple bicyclic quinone molecules, as well as multiple copies thereof covalently attached to a long polyglutamate-based polymeric chain, were examined as new inhibitors of various naturally occurring strains of influenza A virus. The polymer-conjugated in...

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Bibliographic Details
Main Authors: Larson, Alyssa Maxine, Wang, Hongmei, Cao, Yang, Jiang, Taijiao, Chen, Jianzhu, Klibanov, Alexander M.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Wiley Blackwell 2013
Online Access:http://hdl.handle.net/1721.1/76224
https://orcid.org/0000-0003-3830-714X
https://orcid.org/0000-0002-5687-6154

Internet

http://hdl.handle.net/1721.1/76224
https://orcid.org/0000-0003-3830-714X
https://orcid.org/0000-0002-5687-6154

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