Conjugating drug candidates to polymeric chains does not necessarily enhance anti-influenza activity
Using the plaque reduction assay, relatively simple bicyclic quinone molecules, as well as multiple copies thereof covalently attached to a long polyglutamate-based polymeric chain, were examined as new inhibitors of various naturally occurring strains of influenza A virus. The polymer-conjugated in...
Main Authors: | Larson, Alyssa Maxine, Wang, Hongmei, Cao, Yang, Jiang, Taijiao, Chen, Jianzhu, Klibanov, Alexander M. |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Biological Engineering |
Format: | Article |
Language: | en_US |
Published: |
Wiley Blackwell
2013
|
Online Access: | http://hdl.handle.net/1721.1/76224 https://orcid.org/0000-0003-3830-714X https://orcid.org/0000-0002-5687-6154 |
Similar Items
-
Conjugation to polymeric chains of influenza drugs targeting M2 ion channels partially restores inhibition of drug-resistant mutants
by: Larson, Alyssa Maxine, et al.
Published: (2015) -
Bifunctional polymeric inhibitors of human influenza A viruses
by: Haldar, Jayanta, et al.
Published: (2009) -
Bifunctional Polymeric Inhibitors of Human Influenza A Viruses
by: Haldar, Jayanta, et al.
Published: (2012) -
Antiviral polymeric drugs and surface coatings
by: Larson, Alyssa Maxine
Published: (2013) -
Hydrophobic Polycationic Coatings Disinfect Poliovirus and Rotavirus Solutions
by: Larson, Alyssa Maxine, et al.
Published: (2012)