Intra-articular Injection of HB-IGF-1 Sustains Delivery of IGF-1 to Cartilage through Binding to Chondroitin Sulfate

Intra-articular Injection of HB-IGF-1 Sustains Delivery of IGF-1 to Cartilage through Binding to Chondroitin Sulfate

Objective: Insulin-like growth factor 1 (IGF-1) stimulates cartilage repair but is not a practical therapy due to its short half-life. We have previously modified IGF-1 by adding a heparin-binding domain and have shown that this fusion protein (HB-IGF-1) stimulates sustained proteoglycan synthesis...

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Bibliographic Details
Main Authors: Miller, Rachel Elizabeth, Grodzinsky, Alan J., Cummings, Kiersten, Plaas, Anna H. K., Cole, Ada A., Lee, Richard T., Patwari, Parth
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Wiley Blackwell 2013
Online Access:http://hdl.handle.net/1721.1/76249
https://orcid.org/0000-0002-8911-7998
https://orcid.org/0000-0002-4942-3456

Internet

http://hdl.handle.net/1721.1/76249
https://orcid.org/0000-0002-8911-7998
https://orcid.org/0000-0002-4942-3456

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