Derlin-2-Deficient Mice Reveal an Essential Role for Protein Dislocation in Chondrocytes

Protein quality control is a balance between chaperone-assisted folding and removal of misfolded proteins from the endoplasmic reticulum (ER). Cell-based assays have been used to identify key players of the dislocation machinery, including members of the Derlin family. We generated conditional knock...

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Detalhes bibliográficos
Principais autores: Ploegh, Hidde, Kim, Jun, Dougan, Stephanie K., Hu, Chih-Chi Andrew, Paquet, Marie-Eve, Greenblatt, Matthew B., Lilley, Brendan N., Watson, Nicki
Outros Autores: Massachusetts Institute of Technology. Department of Biology
Formato: Artigo
Idioma:en_US
Publicado em: American Society for Microbiology 2013
Acesso em linha:http://hdl.handle.net/1721.1/76251
https://orcid.org/0000-0002-1090-6071