High precision particle mass sensing using microchannel resonators in the second vibration mode
An intrinsic uncertainty in particle mass sensing with the suspended microchannel resonator results from variation in a particle's position near the free end of the resonator. To circumvent this error we employ the second flexural bending mode. This mode exhibits additional frequency peaks whil...
| Main Authors: | , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
American Institute of Physics (AIP)
2013
|
| Online Access: | http://hdl.handle.net/1721.1/76293 https://orcid.org/0000-0001-5223-9433 |
| _version_ | 1826204906830168064 |
|---|---|
| author | Lee, Jungchul Bryan, Andrea Kristine Manalis, Scott R. |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Lee, Jungchul Bryan, Andrea Kristine Manalis, Scott R. |
| author_sort | Lee, Jungchul |
| collection | MIT |
| description | An intrinsic uncertainty in particle mass sensing with the suspended microchannel resonator results from variation in a particle's position near the free end of the resonator. To circumvent this error we employ the second flexural bending mode. This mode exhibits additional frequency peaks while particles pass over the antinode, a point where the frequency shift is insensitive to the lateral position of the particle. We measure polystyrene beads with the first and second modes and confirm that the second mode sensing provides a narrower mass histogram. For 3 μm diameter beads, second mode sensing at the antinode improves the coefficient of variation in buoyant mass from 1.76% to 1.05% for population measurements and from 1.40% to 0.53% for a single trapped particle. |
| first_indexed | 2024-09-23T13:03:15Z |
| format | Article |
| id | mit-1721.1/76293 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:03:15Z |
| publishDate | 2013 |
| publisher | American Institute of Physics (AIP) |
| record_format | dspace |
| spelling | mit-1721.1/762932022-09-28T11:45:35Z High precision particle mass sensing using microchannel resonators in the second vibration mode Lee, Jungchul Bryan, Andrea Kristine Manalis, Scott R. Massachusetts Institute of Technology. Department of Biological Engineering Lee, Jungchul Bryan, Andrea Kristine Manalis, Scott R. An intrinsic uncertainty in particle mass sensing with the suspended microchannel resonator results from variation in a particle's position near the free end of the resonator. To circumvent this error we employ the second flexural bending mode. This mode exhibits additional frequency peaks while particles pass over the antinode, a point where the frequency shift is insensitive to the lateral position of the particle. We measure polystyrene beads with the first and second modes and confirm that the second mode sensing provides a narrower mass histogram. For 3 μm diameter beads, second mode sensing at the antinode improves the coefficient of variation in buoyant mass from 1.76% to 1.05% for population measurements and from 1.40% to 0.53% for a single trapped particle. United States. Army Research Office (Institute of Collaborative Biotechnologies Grant DAAD1903D0004) National Institutes of Health (U.S.) (EUREKA R01GM085457) 2013-01-17T21:07:28Z 2013-01-17T21:07:28Z 2011-02 2010-06 Article http://purl.org/eprint/type/JournalArticle 0034-6748 http://hdl.handle.net/1721.1/76293 Lee, Jungchul, Andrea K. Bryan, and Scott R. Manalis. “High Precision Particle Mass Sensing Using Microchannel Resonators in the Second Vibration Mode.” Review of Scientific Instruments 82.2 (2011): 023704. © 2011 American Institute of Physics https://orcid.org/0000-0001-5223-9433 en_US http://dx.doi.org/10.1063/1.3534825 Review of Scientific Instruments Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Institute of Physics (AIP) MIT Web Domain |
| spellingShingle | Lee, Jungchul Bryan, Andrea Kristine Manalis, Scott R. High precision particle mass sensing using microchannel resonators in the second vibration mode |
| title | High precision particle mass sensing using microchannel resonators in the second vibration mode |
| title_full | High precision particle mass sensing using microchannel resonators in the second vibration mode |
| title_fullStr | High precision particle mass sensing using microchannel resonators in the second vibration mode |
| title_full_unstemmed | High precision particle mass sensing using microchannel resonators in the second vibration mode |
| title_short | High precision particle mass sensing using microchannel resonators in the second vibration mode |
| title_sort | high precision particle mass sensing using microchannel resonators in the second vibration mode |
| url | http://hdl.handle.net/1721.1/76293 https://orcid.org/0000-0001-5223-9433 |
| work_keys_str_mv | AT leejungchul highprecisionparticlemasssensingusingmicrochannelresonatorsinthesecondvibrationmode AT bryanandreakristine highprecisionparticlemasssensingusingmicrochannelresonatorsinthesecondvibrationmode AT manalisscottr highprecisionparticlemasssensingusingmicrochannelresonatorsinthesecondvibrationmode |